歴史・沿革／会社概要

代表取締役　樋口 正人

1985年3月

千葉大学大学院理学研究科生物学専攻修了。

1985年4月

中外製薬株式会社に入社し、新薬研究所に配属。
腎性貧血治療を目的としたバイオ医薬「エポジン」を創薬。

1999年4月より

筑波大学先端学際研究センター（山本雅之教授）客員研究員。

2007年4月より

金沢医科大学医学部（腎臓内科）非常勤講師。

2007年11月

中外製薬退社。

2008年1月

株式会社エムシープロットバイオテクノロジー入社。

2009年5月

株式会社ダステック設立。

2016年3月より

一般社団法人日本ファンクショナルダイエット協会認定　
シニアケトジェニックダイエットアドバイザー

2016年4月より

一般社団法人AGE研究協会　認定講師

所属団体

  • 日本透析医学会
  • 日本抗加齢医学会
  • 日本糖質制限医療推進協会

業績（文献）リスト

  • 樋口正人

    新しい炭素材ダイエタリーカーボンの生理機能

    FOOD STYLE 21 2013 17(5):

  • Hara A, Furuichi K, Higuchi M, Iwata Y, Sakai N, Kaneko S, Wada T.

    Autoantibodies to erythropoietin receptor in patients with immune-mediated diseases: relationship to anaemia with erythroid hypoplasia.

    Br J Haematol. 2013 Jan;160(2):244-50.

  • Yanagawa T, Toba K, Kato K, Suzuki T, Minagawa S, Saigawa T, Ozawa T, Oda M, Takayama T, Hanawa H, Higuchi M, Saito H, Aizawa Y.

    Asialoerythropoietin exerts stronger angiogenic activity than erythropoietin via its binding affinity to tissue.

    Cardiovasc Drugs Ther. 2013 Apr;27(2):117-24.

  • Moriyama M, Toba K, Hanawa H, Kato K, Yanagawa T, Takayama T, Ozawa T, Kobayashi H, Higuchi M, Saito H, Aizawa Y.

    A novel synthetic derivative of human erythropoietin designed to bind to glycosaminoglycans.

    Drug Deliv. 2012 May;19(4):202-7.

  • Suzuki H, Toba K, Kato K, Ozawa T, Tomosugi N, Higuchi M, Kusuyama T, Iso Y, Kobayashi N, Yokoyama S, Fukuda N, Saitoh H, Akazawa K, Aizawa Y.

    Serum hepcidin-20 is elevated during the acute phase of myocardial infarction.

    Tohoku J Exp Med. 2009 Jun;218(2):93-8.

  • Hara A, Wada T, Kitajima S, Toyama T, Okumura T, Kitagawa K, Iwata Y, Sakai N, Furuichi K, Higuchi M, Kaneko S.

    Combined pure red cell aplasia and autoimmune hemolytic anemia in systemic lupus erythematosus with anti-erythropoietin autoantibodies.

    Am J Hematol. 2008 Sep;83(9):750-2.

  • Hamada Y, Kono TN, Moriguchi Y, Higuchi M, Fukagawa M.

    Alteration of mRNA expression of molecules related to iron metabolism in adenine-induced renal failure rats: a possible mechanism of iron deficiency in chronic kidney disease patients on treatment.

    Nephrol Dial Transplant. 2008 Jun;23(6):1886-91.

  • Itoh K, Sawasaki Y, Takeuchi K, Kato S, Imai N, Kato Y, Shibata N, Kobayashi M, Moriguchi Y, Higuchi M, Ishihata F, Sudoh Y, Miura S.

    Erythropoietin-induced proliferation of gastric mucosal cells.

    World J Gastroenterol. 2006 Jan 14;12(2):234-9.

  • Tomosugi N, Kawabata H, Wakatabe R, Higuchi M, Yamaya H, Umehara H, Ishikawa I.

    Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System(R).

    Blood. 2006 Apr 18; [Epub ahead of print]

  • Yiwen Li, Genzou Takemura, Hideshi Okada, Shusaku Miyata, Rumi Maruyama, Longhu Li, Masato Higuchi, Shinya Minatoguchi, Takako Fujiwara and Hisayoshi Fujiwara

    Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure.

    Cardiovasc Res. 2006 Jun 6; [Epub ahead of print]

  • Kawano-Yamamoto C, Muroi K, Nagatsuka Y, Higuchi M, Kikuchi S, Nagai T, Hakomori SI, Ozawa K

    Establishment and characterization of a new erythroblastic leukemia cell line, EEB: phosphatidylglucoside-mediated erythroid differentiation and apoptosis.

    Leuk Res. 2006 Jul;30(7):829-39.

  • Nagayoshi K, Ohkawa H, Yorozu K, Higuchi M, Higashi S, Kubota N, Fukui H, Imai N, Gojo S, Hata J, Kobayashi Y, Umezawa A

    Increased mobilization of c-kit+ Sca-1+ Lin- (KSL) cells and colony-forming units in spleen (CFU-S) following de novo formation of a stem cell niche depends on dynamic, but not stable, membranous ossification.

    J Cell Physiol. 2006 Jul;208(1):188-94.

  • 樋口正人

    エリスロポエチンの基礎、遺伝子と構造

    エリスロポエチンのすべて（平澤由平、平嶋邦猛監修　メディカルレビュー社）2005 35-42,.

  • Maruyama H, Higuchi M, Higuchi N, Kameda S, Saito M, Sugawa M, Matsuzaki J, Neichi T, Yokoyama S, Miyazaki Y, Miyazaki J, Gejyo F.

    Post-secretion neutralization of transgene-derived effect: soluble erythropoietin receptor/IgG1Fc expressed in liver neutralizes erythropoietin produced in muscle.

    J Gene Med. 2004 Feb;6(2):228-37.

  • Okoshi Y, Imagawa S, Higuchi M, Yoshida C, Shimizu S, Mukai HY, Komeno T, Hasegawa Y, Ninomiya H, Kojima H, Nagasawa T.

    A patient with acquired pure red cell aplasia showing a positive antiglobulin test and the presence of inhibitor against erythroid precursors.

    Intern Med. 2002 Jul;41(7):589-92.

  • Takeshita A, Shinjo K, Naito K, Ohnishi K, Higuchi M, Ohno R.

    Erythropoietin receptor in myelodysplastic syndrome and leukemia.

    Leuk Lymphoma. 2002 Feb;43(2):261-4. Review.

  • Imagawa S, Tarumoto T, Suzuki N, Mukai HY, Hasegawa Y, Higuchi M, Neichi T, Ozawa K, Yamamoto M, Nagasawa T.

    L-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with L-NMMA.

    Kidney Int. 2002 Feb;61(2):396-404.

  • Imagawa S, Yamaguchi Y, Higuchi M, Neichi T, Hasegawa Y, Mukai HY, Suzuki N, Yamamoto M, Nagasawa T.

    Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea--hypopnea syndrome.

    Blood. 2001 Aug 15;98(4):1255-7.

  • Akihiro Takeshita, Kaori Shinjo, Kensuke Naito, Kazunori Ohnishi, Masato Higuchi, Ryuzo Ohno

    Erythropoietin receptor in myelodysplastic syndrome and leukemia.

    Leukemia and Lymphoma, 2002 43(2):261-264.

  • Shigehiko Imagawa, Yuji Yamaguchi, Masato Higuchi, Tomohiro Neichi, Yuichi Hasegawa, Harumi Y. Mukai, Norio Suzuki, Masayuki, Yamamoto, and Toshiro Nagasawa

    Levels of Vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome.

    Blood 2001 98 (4):1255-1257.

  • 樋口正人、今井信雄

    エリスロポエチン産生調節と酸素分圧感知機構

    細胞　2001 33 :424-427.

  • 樋口正人、根市知宏

    新しいrHuEPO療法、経口製剤開発の可能性

    腎と透析 2001 51:223-227.

  • Tarumoto T. Imagawa S. Ohmine K. Nagai T. Higuchi M. Imai N. Suzuki N. Yamamoto M. Ozawa K.

    N(G)-monomethyl-L-arginine inhibits erythropoietin gene expression by stimulating GATA-2.

    Blood. 2000 96(5):1716-22.

  • Takeshita A. Shinjo K. Higuchi M. Miyawaki S. Takemoto Y. Kishimoto Y. Saito K. Takuchi H. Kuriyama K. Kimura Y. Asou N. Takahashi M. Hotta T. Kanamaru A. Ueda R. Ohno R.

    Quantitative expression of erythropoietin receptor (EPO-R) on acute leukaemia cells: relationships between the amount of EPO-R and CD phenotypes, in vitro proliferative response, the amount of other cytokine receptors and clinical prognosis. Japan Adult Leukaemia Study Group.

    British Journal of Haematology. 2000 Jan108(1):55-63.

  • Miyazaki Y. Kuriyama K. Higuchi M. Tsushima H. Sohda H. Imai N. Saito M. Kondo T. Tomonaga M.

    Establishment and characterization of a new erythropoietin-dependent acute myeloid leukemia cell line, AS-E2.

    Leukemia. 1997 Nov 11(11):1941-9.

  • Shinjo K. Takeshita A. Higuchi M. Ohnishi K. Ohno R.

    Erythropoietin receptor expression on human bone marrow erythroid precursor cells by a newly-devised quantitative flow-cytometric assay.

    British Journal of Haematology. 1997 Mar 96(3):551-8.

  • 樋口正人、今井信雄

    エリスロポエチンレセプター

    腎と透析1995 39:23-28.

  • Higuchi M. Oh-eda M. Kuboniwa H. Tomonoh K. Shimonaka Y. Ochi N.

    Role of sugar chains in the expression of the biological activity of human erythropoietin.

    Journal of Biological Chemistry. 1992 Apr 267(11):7703-9.

  • Cynshi O. Shimonaka Y. Higuchi M. Imai N. Suzuki H. Togashi M. Okamoto MT. Hirashima K.

    Effects of recombinant human erythropoietin on haemolytic anaemia in mice.

    British Journal of Haematology. 1990 Nov 76(3):414-9.

  • Imai N. Higuchi M. Kawamura A. Tomonoh K. Oh-Eda M. Fujiwara M. Shimonaka Y. Ochi N.

    Physicochemical and biological characterization of asialoerythropoietin. Suppressive effects of sialic acid in the expression of biological activity of human erythropoietin in vitro.

    European Journal of Biochemistry. 1990 Dec 194(2):457-62.

  • Matsumoto T. Endoh K. Kamisango K. Akamatsu K. Koizumi K. Higuchi M. Imai N. Mitsui H. Kawaguchi T.

    Effect of recombinant human erythropoietin on anticancer drug-induced anaemia.

    British Journal of Haematology. 1990 Aug 75(4):463-8.

  • Kawamura A. Higuchi M. Imai N. Kawaguchi T. Ogura Y.

    Effect of purified recombinant human erythropoietin on anemia in rats with experimental renal failure induced by five-sixth nephrectomy.

    Biotherapy. 1990 2(1):77-85.

  • Cynshi O. Satoh K. Higuchi M. Imai N. Kawaguchi T. Hirashima K.

    Effects of recombinant human erythropoietin on anaemic W/Wv and Sl/Sld mice.

    British Journal of Haematology. 1990 Jul 75(3):319-24.

  • 河村明典、山本　要、落合宏典、佐々木千秋、駒村全美、清水トシ子、樋口正人、

    今井信雄、川口　勉、渡辺一郎、水野光司

    遺伝子組換えヒトエリスロポエチンEPOCHの生物学的性質

    臨床医薬 1990 6 Suppl.2 : 28-32

  • 樋口正人、下中　靖、進士　修、河村明典、友納喜久雄、越智教道、今井信雄

    Recombinant human erythropoietinの各種血液細胞に対する結合

    臨床医薬1990 6 Suppl.2 : 28-32.